Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells

Radiosensitizing effect of deferoxamine on human glioma cells

ABSTRACT Background: Tumor cells exhibit an increased requirement for iron to support their rapid proliferation. Deferoxamine (DFO), an iron chelator, has been reported to have anti-proliferative effects on cancer cells through induction of apoptosis and cell cycle arrest. X-rays also induce apoptosis and cell cycle arrest. However, limited information is available regarding the effect of iron...

Selective COX-2 Inhibitor (Rofecoxib) Inhibits Vinorelbine Cytotoxicity in C6 Glioma Cells In Vitro

We examined the effects of gemcitabine, a novel nucleotide analogue, and vinorelbine, a semi-synthetic vinca alcaloid, in C6 glioma cell culture. We simultaneously monitored the modulation of its activity in combination with the telomerase inhibitory agent dimetilsülfoxid and with a specific cyclooxygenase-2 inhibitory agent Rofecoxib. The effects of the gemcitabine/ vinorelbine combination wer...

Selective COX-2 Inhibitor (Meloxicam) and Tooth-Supporting Bone Quality. A Histomorphometric Study in Rats.

The effects of the non-steroidal anti-inflammatory drugs (NSAIDs) on bone quantity and quality were investigated for years. However, there is lack of information on the impact of NSAIDs on the quality of tooth-supporting alveolar bone in absence of periodontal inflammation. Thus, the aim of this study was to evaluate histometrically the influence of a selective COX-2 NSAID (Meloxicam) on the in...

The effect of meloxicam, a selective COX-2 inhibitor, on the microvasculature of small metastatic liver tumors in rats.

BACKGROUND COX-2 is involved in tumor angiogenesis and modulation of the production of angiogenetic factors by colorectal carcinoma cells. It has been shown that COX-2 inhibitors have inhibitory activities against various types of tumor, including colorectal carcinoma. In this study, we investigated the tumor vessels of small metastatic liver tumors in rats and the effect of meloxicam, a select...

synthesis of 3-(2-(benzyloxy)phenyl)-5-(methylsulfonyl)-4h-1,2,4-triazole as selective cox-2 inhibitor